Promotin
Promoting the recovery of neurologic function and antagonizing cell apoptosis in ICH model rats by Induced Pluripotent Stem Cell Transplantation*
Jing Qi1#, Jie Qin1#, Guangming Gong2,Bo Song1 , Huili Zhang1, Yanlin Wang1, Haiyun Qi1, Bo Yang3, Yi Zhang4, Yuming Xu1*, Shilei Sun1*
1. The Third Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,Henan 450052, China
2. Department of Microbiology and Immunology, College of Basic Medicine, Zhengzhou University, Zhengzhou, Henan 450001, China
3.Neurosurgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan 450052, China
4.Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Abstract: Intracerebral hemorrhage (ICH) is a major disease that seriously threatens human health; it features high fatality rate and disability rate and often leaves severe neurologic dysfunction even after recovery. The effect of induced pluripotentstem cells (iPSCs) transplantation on the recovery of the neurologic dysfunction of ICH is still uncertain. We prepared ICH rat models by injecting collagenase to the striatum of rats through stereotaxic apparatus, injected derived from ICH patients around the hematoma to evaluate the dynamic changes of neurologic function on day 1, 3, 7, 14 and 28 after ICH treatment by iPSCs transplantation with modified neurological severity score (mNSS) table, and studied the cell apoptosis changes around the hematoma. We found out that the neurological scores of rats were obviously improved and the apoptotic cells were significantly reduced compared with the model group. Our research results showed that iPSCs transplantation can effectively promote the recovery of neurologic function of ICH rats and antagonize cellapoptosis induced by encephalorrhagia.
[Qi J, Qin J, Song B, Zhang HL, Wang YL, Yang YK, Qi HY, Gong GM, Xu YM, Sun SL. Promoting the recovery of neurologic function and antagonizing cell apoptosis in ICH model rats by Induced Pluripotent Stem Cell Transplantation. Life Sci J 2013;10(1):280-284] (ISSN:1097-8135). http://www.lifesciencesite.com. 43
Key words：induced pluripotent stem cells (iPSCs), intracerebral hemorrhage (ICH), apoptosis Full Text 43
