Nutrition
Nutrition with polyunsaturated
fatty acid and lower carbohydrate diet has controlled poly cystic ovarian
syndrome, on poly cystic ovarian (PCO) induces rats
Elaheh
Ouladsahebmadarek1, Arash Khaki2¬, Laya Farzadi1, Afshin Zahedi 3
1-Women’s Reproductive
Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Pathology,
Tabriz Branch, Islamic Azad University, Tabriz, Iran (Correspondences
Author, [email protected])
3. Department of Pathology,
Rasht Branch, Islamic Azad University, Rasht, Iran
Abstract: PCOS
produces symptoms in approximately 5% to 10% of women of reproductive age
(12–45 years old). It is thought to be one of the leading causes of female subfertility. To confirm the role of nutrition with omega-3
polyunsaturated fatty acid on controlled of experimental PCO induced by
estradiol-valerat (PPA) in rats, this study was done. Wistar female rat (n=50) were allocated into control (n=10)
and test groups (n=40), test group subdivided into groups of 4, G1, received
omega-3 (60 mg/rat/orally/daily),G2 induced PCO by single injection of
estradiol-valerate (4mg/rat/IM), G3 and G4 groups were induced PCO by single
injection of estradiol-valerate (4mg/rat/IM),G3 & G4 groups was
received omega-3 (60 mg/rat) ,and G4, received lower carbohydrate feeding
,for 60 consequence day. In sixty day 5cc blood samples and ovarian tissues of
Rats in whole groups were removed and prepared to biochemical pathological
analysis. hemorrhage, hyperemia and fibrosis were seen in pco groups,
these side effects in groups that received omega-3 and lower
carbohydrate feeding, significantly decreased (p<0.05) in comparison to
experiment groups and ovarian weights in both experimental and control group
were similar(p<0.05). Results revealed that administration of omega-3 plus
lower carbohydrate food significantly controlled PCO syndrome.
[Elaheh
Ouladsahebmadarek, Arash Khaki, Laya Farzadi, Afshin
Zahedi. Nutrition with polyunsaturated fatty
acid and lower carbohydrate diet has controlled poly cystic ovarian syndrome,
on poly cystic ovarian (PCO) induces rats. Life Sci J 2013;10(1):1171-1175]
(ISSN: 1097-8135). http://www.lifesciencesite.com.
Key words: Carbohydrate, Omega-3, Nutrition, Ovary, PCO.
