Assessment
Assessment of Pravastatin effects on
healing of bone defect in rats
Ghafour Mousavi1*,
Daryoush Mohajeri2
1Department of Clinical Science, Faculty of Veterinary
Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran (Corresponding
author, Email: [email protected])
2Department of Pathobiology, Faculty of Veterinary
Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract: Statins
are a commonly prescribed cholesterol-lowering drug; however, it has recently
been shown that they also have the beneficial side effect of enhancing bone
matrix formation. As a result,
this study is to assay probability effect of Pravastatin on osteogenesis which
is made in experimental flaw and it is as a laboratory pattern in rat femur.
This experimental study was conducted on 30 male SD rats. Animals were divided
randomly into 3 groups (control and experimental). After
induction of general anesthesia, a hole in size of 2 mm in diameter was made
using a dental bit in femur width to medullary channel. After surgery, the
control group received orally sterile water daily and experimental groups 1 and
2 respectively received daily 10 and 20 mg/kg/PO of Pravastatin. Histopathological
and histomorphometrical studies for evaluation of bone healing were carried out
in experimental rats, which were euthanized after 45 days of the experiment. In
control group, defect seemed to be filled with woven bone and bone marrow
spaces and in spite of a poor osteogenic activity. In experiment groups, many
osteoblasts groupings, and young bone trabeculas increased in number and bone
trabeculas more organized. Histomorphometric results, observed that Pravastatin
has significant effect on bone healing in experimental groups 2 and 3 than
control group (p=0/000), analyzing obtained results
show thatPravastatin has significant effect in group 3 that received high
dosage of Pravastatin than group 2 (p=0/000). The results of this study show
that Pravastatin could stimulate osteogenesis in rats.
[Ghafour
Mousavi, Daryoush Mohajeri. Assessment of Pravastatin effects on
healing of bone defect in rats.Life Sci J 2013;10(1):1206-1209] (ISSN: 1097-8135). http://www.lifesciencesite.com.
Keywords: Pravastatin, bone healing, Rat, Histopathology, Histomorphometry
