Anesthetic
Anesthetic
Induction with Propofol versus Ketamine Pre and Post Lower Pole Nephrectomy in
Dogs
Shekidef, M. H1.;
Helal, I. E2 and Ramadan, Taha3
Department of Surgery,
Anesthesiology and Radiology, Faculty of Veterinary Medicine, Suez Canal
University1, Experimental Surgery Unit, King Fahd Medical Research
Center, King Abdul Aziz University2& Department of Clinical
Pathology, Faculty of Veterinary Medicine, Suez Canal University3.
Abstract: This
study was performed on fourteen Mongrel dogs to compare anesthetic
induction in healthy, as well as, partially nephrectomized dogs using bolus
intravenous administration of either propofol 4 mg/kg b.wt.in group I
(before nephrectomy) and group II (one month after lower pole nephrectomy) or
ketamine 10 mg/kgb.wt. in group III (before
nephrectomy) and group IV (one month after lower pole nephrectomy). The quality
of induction and recovery, the occurrence of cardiovascular and respiratory
side effects and serum biochemical parameters were investigated. The results
revealed that, anesthetic induction time did not change significantly in dogs
before and after nephrectomy under the effect of either propofol or ketamine.
Meanwhile, ketamine induced significantly longer weak time and down time than
did propofol in corresponding groups. RRF was significantly longer in
nephrectomized than non nephrectomized dogs under the effect of both agents
while, recovery time was significantly longer in nephrectomized than non
nephrectomized dogs under the effect of propofol. Ketamine caused significantly
longer recovery time than did propofol in corresponding groups. There were no
significant differences in induction and recovery scores before and after
nephrectomy in dogs anesthetized with either propofol or ketamine. However,
propofol caused significantly better induction and recovery than did ketamine
in corresponding groups. Propofol caused significant decrease but ketamine
caused significant increase in heart rate and respiratory rate in both
nephrectomized and non nephrectomized dogs. Meanwhile, they did not
significantly alter rectal temperature. ECG tracings showed only change in
heart rate without arrhythmias. Significant increases in AST, LDH, CPK, urea
and creatinine were observed in all groups with minor disparity from one to
another group. It could be concluded that ketamine had better cardiopulmonary
effect than propofol but the later was superior in the quality of induction and
recovery. Lower pole nephrectomy in dogs had minimal impact on the modality of
the effect of either agent.
[Shekidef, M. H.;Helal, I. E. and Ramadan, Taha. Anesthetic Induction with Propofol versus Ketamine Pre and Post Lower Pole Nephrectomy in Dogs. Life Sci J 2013;10(1):3070-3080]. (ISSN: 1097-8135).http://www.lifesciencesite.com.
Key words: Dog – ketamine – nephrectomy - propofol.
