Effect of G
Effect
of Ginger Extract on Deltamethrin Induced Histomorphological and
Immunohistochemical Changes in Testes of Albino Rats
Saber A. Sakr1,
Wael M. Al-Amoudi2
1Zoology Department, Faculty of Science, Menoufia
University, Shebin El-kom, Egypt
2Department of Biology, Faculty of Applied Sciences,
Umm Al-Qura University, Makkah, Saudi Arabia.
Abstract:The
current study investigated the effect of ginger{Zingiberofficinale Roscoe(Zofficinale R.}extract
on deltamethrin induced testicular damage in albino rats. Treating animals with
deltamethrin at a dose level of 1/10 LD50, 3 days
weekly for 6 weeks caused a decrease in body and
testes weights. Remarkable decreases were also noted in sperm cell
concentrations and sperm motility. In addition histopathological results
revealed degeneration of spermatogenic cells, congestion of blood vessels and
destruction of Leydige cells.The diameters of the seminiferous tubules and
heights of their germinal epithelium were significantly reduced. Immunohistochemical results showed that Bax
expression was increased in Leydige cells and p53 expression increased in
spermatocytes of testes of deltamethrin treated rats. According to these
results, deltamethrin induced oxidative stress and caused apoptosis in testes
of albino rats. Treating animals with deltamethrin and ginger revealed an
improvement in the histological changes observed in animals treated with
deltamethrin and increased sperm concentration and motility. Moreover,
ginger treatment leads to a decrease in the expression of p53 and bax. This
effect of ginger extract may be attributed to its antioxidant activity.
[Saber A. Sakrand Wael M. Al-Amoudi. Effect of
Ginger Extract on Deltamethrin Induced Histomorphological and
Immunohistochemical Changes in Testes of Albino Rats. Life Sci J
2012;9(1):771-778]. (ISSN: 1097-8135).http://www.lifesciencesite.com.111
Keywords: Deltamethrin, testes, ginger, apoptosis,
p53,Bax. Full Text 111
