The distrib
The distribution changes and significance of mTOR in the differentiation of rat bone marrow mesenchymal stem cells into neurons
WANG Cuiqin, JIA Yanjie, ZHANG Gangyu, PENG Yue, PENG Tao*
Department of Neurology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China
E-mail address: [email protected]
ABSTRACT: Bone marrow mesenchymal stem cells (MSCs) are known to differentiate into neurons in vitro. However, the mechanism underlying MSCs differentiation remains controversial. mTOR (the mammalian target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis.This study is to investigate the distribution changes and significance of mTOR in the differentiation of (MSCs) into neurons. We found that during the induction of MSCs to neurons, mTOR transfered into cytoplasm from nuclear, and the activity of mTOR declined. mTOR might play an important role in regulating MSCs differentiation into neurons.
[WANG Cuiqin, JIA Yanjie, ZHANG Gangyu, PENG Yue, PENG Tao. The distribution changes and significance of mTOR in the differentiation of rat bone marrow mesenchymal stem cells into neurons. Life Sci J 2013;10(1):1508-1511] (ISSN:1097-8135). http://www.lifesciencesite.com. 2
KEYWORDS: Bone marrow mesenchymal stem cells; Induction; Neurons; mTOR; Rapamycin
