Utility of
Utility of 2-Thiohydantoin Derivatives in the Synthesis
of Some Condensed Heterocyclic Compounds with Expected Biological Activity
A.Y. Hassan1,
M.M.Said2; M.T. Sarg3; H.S.Al-Zahabi4 and
E.M.Hussein3
1Department of Chemistry, Faculty of Science (Girls),
Al-Azhar University, Nasr City, Cairo; Egypt
2Department of Organic Chemistry, Faculty of Pharmacy,
Cairo University, Cairo;
Egypt
3Department
of Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr
City, Cairo; Egypt
4Department of Pharmaceutical
Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo.
Egypt
Abstract: On
the pharmaceutical account of the reported anticancer activity of
imidazole and condensed imidazole, new imidazo [2,1-b][1,3,5]thiadiazines 3a-d
, pyrrolo[1,2-e]imidazole 5, imidazo[2,1-b][1,3]thiazines6a,b,
6a, imidazo[2,1-b][1,3]benzothiazines 7a,b, 9a,b imidazo[2,1-b][1,3]thiazoles 11a,b,
12a,b, 18a,b, 19a,b, 20a,b, 24; thieno[3,2,:4,5]pyrimido[1,2-a]imidazoles 14a,b,
15a,b, pyrido[3',2':4,5]thieno[3,2-d]imidazo[1,2-a]pyrimidines 17a,b
, imidazole derivatives 8a,b, 10a,b, 21, 22, 23 and
imidazo[2,1:2,3]thiazolo[4,5-c]pyrazole25 were
synthesized through different chemical reactions. Structures of all synthesized
compounds were supported by spectral and elemental analyses. The selected
compounds by NCI were evaluated for their in vitro antitumor
activity against 60 human tumour cell lines.
[A.Y. Hassan, M.M.Said; M.T. Sarg; H.S.Al-Zahabi
and E.M.Hussein. Utility of 2-Thiohydantoin Derivatives in the
Synthesis of Some Condensed Heterocyclic Compounds with Expected Biological
Activity. Life Sci J2013;10(1):1993-] (ISSN:1097-8135). http://www.lifesciencesite.com.
Keywords: imidazo[2,1-b][1,3,5]thiadiazine; imidazo[2,1-b][1,3]thiazine, imidazo [2,1-b] thiazole; imidazole derivatives; anticancer .
