Assessment o
Assessment of Zinc and Copper
Contents in the Hair and Serum and Also Superoxide Dismutase, Glutathion
Peroxidase and Malondi Aldehyde in Serum in Androgenetic Alopecia and Alopecia
Areata
Mehdi Amirnia1,
Sima Sinafar2, Hassan Sinafar3, Mohammad Nuri4,
Abdoreza Taban Sadeghi5
1. Associated professor of Dermatology,
Department of Dermatology, Faculty of Medicine, Tabriz University of Medical
Sciences, Tabriz, Iran
2. General physician, Faculty of
Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3. Dermatologist, Department of
Dermatology, Faculty of Medicine, Tabriz University of Medical Sciences,
Tabriz, Iran
4. Associated professor of
Biochemistry, Department of Biochemistry, Tabriz University of Medical Sciences, Iran
5- Pathologist,
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: Alopecia areata (AA) is a recurrent nonscarring
type of hair loss that can affect any hair-bearing area. Androgenetic alopecia
(AGA) or male pattern hair loss is a very common condition that has a
significant psychosocial impact for patients. There are claims that
imbalance of trace elements may trigger the onset of alopecia. The aim of this
research was to assess the level of zinc, copper contents in the hair and level
of lipid peroxidation as super oxide dismutase, Glutathion peroxidase and malon
di aldehyde in serum in androgenic and areata alpecia. The prospective study
was conducted in department of Dermatology of Sina Hospital and Biochemistry
department of Tabriz University of medical science. The study population
consists of 27 patients with alopecia areata and 27 patients with androgenetic
alopecia. 27 age and sex matched healthy control subjects were studied.
The level of zinc, copper contents in the hair and serum and level of lipid
peroxidation as super oxide dismutase (SOD), Glutathion peroxidase(GPX-Px) and
malon di aldehyde (MDA) in serum in androgenetic, areata alpecia and healthy
control subjects were measured in all samples. The collected data were
statistically analyzed, using SPSS. The duration of hair loss varied
between 1-240 month among patients with alopecia areata and 6-180 month among
patients with androgenetic alopecia. The mean of hair zinc level in AA
patients, AGA patients and controls were 98.33 µg/dl, 105.35 µg/dl and
129.52 µg/dl. The mean level of hair copper level in study and control
groups were, 7.91, 7.25 and 10.34. The mean of serum level of SOD, MDA and
GPX-Px in study and control groups were (1945.25, 1861.57 and 2296.77), (3.64,
3.49 and 1.62) and (129.11, 118.84 and 138.74). Zinc and copper contents of
hair and serum were significantly lower among patients with alopecia areata and
androgenetic alopecia compared to controls (P<0.05). The serum level
of SOD, GPX-Px were significantly lower and level of MDA were higher among
patients with alopecia areata and androgenetic alopecia compared to controls (P<0.05).
These results suggest that low levels of zinc and copper of hair and serum and
lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system
(SOD, GPX-Px) with high level of MDA at serum may play a role in the
pathogenesis of AA and AGA.
[Amirnia M, Sinafar S, Sinafar H, Nuri M,
Taban Sadeghi A. Assessment of Zinc and Copper Contents in the Hair and
Serum and Also Superoxide Dismutase, Glutathion Peroxidase and Malondi Aldehyde
in Serum in Androgenetic Alopecia and Alopecia Areata. Life Sci J 2013;10(1):204-209]
(ISSN:1097-8135).http://www.lifesciencesite.com. 30
Keywords: Alopecia; Zinc; Copper Full Text 30
