Association
Association
between CC16 Polymorphism and Bronchial Asthma
Nisreen M.El Abiad1,
Hisham Waheed2, William M. Morcos2, Samar M.
Salem2, and Hala Ataa3, Olfat G. Shaker4
Departments of: 1Pediatric, 4Medical
Biochemistry, Faculty of Medicine, Cairo University, 2Child
Health, NRC. And 3Al Galaa Teaching Hospital, Cairo, Egypt. [email protected]
Abstract: Background:
Asthma is one of the most common chronic pediatric diseases, and is responsible
for a significant proportion of school day losses. Asthma is influenced by
genetic and environmental factors. The inheritance pattern of asthma
demonstrates that it is a complex genetic disorder. Clara cell secretory
protein (CC16) is an ideal candiadate for involvement in an inherited
predisposition to asthma owing to its chromosomal location, nature and
function. Objective: to screen exons of CC16 gene on chromosome 11 for
detection of sequence variation in families to determine whether these allelic
polymorphism are associated with clinical asthma or not and to detect the
relation between type of genetic polymorphism and asthma severity. Patients and
Methods: This study included 20 stable asthmatic children with 21 of their
atopic family members, also 11 healthy non atopic subjects were included as
control group, all cases were subjected to genetic study methods
including pedegree construction, PCR and detection of allelic polymorphism.
Results: Significant correlation (90%) between homozygous CC16, 38 (AA) (75%)
and 38 (AG) (15%) allelic polymorphism and increased prevalence of asthma was
detected in families but there was no correlation between CC16 allelic
polymorphism and asthma severity. Conclusion: There was a correlation between
CC16 allelic polymorphism and increased prevalence of asthma and this gene is
present also in normal subjects who are not triggered by environmental factors.
[Nisreen M.El Abiad, Hisham Waheed, William M. Morcos,
Samar M. Salem, and Hala Ataa, Olfat G. Shaker. Association between
CC16 Polymorphism and Bronchial Asthma. Life Sci J 2012;9(1):265-270].
(ISSN: 1097-8135).http://www.lifesciencesite.com. 36
Key words: CC16- Gene polymorphism – PCR- Asthma Full Text 36
