Peripferal N
Peripferal Nerve Regeneration in
Response to Synthesized Nanofiber Scaffold Hydrogel
Hui Meng1*,
Liyan Chen2, and Xiaojun Zhao2
1*Corresponding author：Pathology Department, First-affiliated
Hospital of Zhengzhou University. Institute for NanoBiomedical Technology and
Membrane Biology, West China Hospital, Sichuan University, Science Park No
1, Ke Yuan 4th St, Gao Peng Road, Hi-tech Industrial Development
Zone, Chengdu, Sichuan 610041, China
2Institute for Nanobiomedical Technology and Membrane
Biology, West China Hospital, Sichuan University, Science
Park No 1, Ke Yuan 4th St, Gao Peng Road, Hi-tech Industrial Development Zone,
Chengdu, Sichuan 610041, China
E-mail: 1,* [email protected];
Abstract: Background: earlier studies have demonstrated that
Peptide RADA16-I (AcN-RADARADARADARADA-CONH2 ) could
repair spinal cord injury and optical pathway and restore visual function. The
objective of the research is to investigate the role of RADA16-I in the
regeneration of peripheral nerve injury in rats. Method: sciatic nerve injury
was performed at female Sprague-Dawley rats. Two groups were conducted: crush
group and sever group. There were RADA16-I treatment and blank control in each
group. Sense Nerve Conduction (SNCV) parameters were EVALUATEDon day 30 in the injured
sciatic nerve by means of electrophysiological recording. The results
indicates that SNCV in test groups shows a faster healing rate than blank
control. Conclusion: self-assembling peptide plays a effective role
in the regeneration of sciatic nerve in rats.
[Hui Meng, Liyan Chen, and Xiaojun Zhao. Peripferal Nerve
Regeneration in Response to Synthesized Nanofiber Scaffold Hydrogel. Life Sci J 2012;9(1):42-46] (ISSN: 1097-8135). http://www.lifesciencesite.com. 8
Keyword: Nanobiology; SAP;
AtomicForce Microscopy; Peripheral nerve healing; Electrophysiological
recording. Full Textttt 8
