Serum Fetuin
Serum
Fetuin-A in Egyptian Pediatrics with
Chronic End-stage Renal Diseases: A Correlation to Vascular Inflammatory
Biomarkers
*Mona F. Schaalan, * Lamiaa
N. Hammad,*Sahar A. Raouf and **Maha A. Abo-Shadi and *** Waleed A.
Mohamed
* Biochemistry
Department, Faculty of Pharmacy, Misr International University **Microbiology
and Immunology Dept., Faculty of Pharmacy, Al-Azhar University,***Chemistry Department, Kasr ELeini Teaching Hospitals, Cairo University,
Cairo, Egypt. [email protected]
Abstract: Background: The incidence of vascular calcification is known
to be elevated in haemodialysis patients. A close relationship does also exist
between inflammation and vascular calcification. Aims: To
understand role of inflammation; we investigated the serum concentrations of
some inflammatory markers in children with end stage renal diseases, and
compared those patients either undergoing haemodialysis or not with their
control counterparts. The potential relationship between serum fetuin-A and the
inflammatory markers in the studied patients was also unraveled. Methodology: In
this prospective non-randomized study, eighty chronic kidney failure pediatric
Egyptian patients were enrolled. Group I included 40 of them who were managed
without haemodialysis, while group II included 40 on regular haemodialysis in
the Center of Pediatric Nephrology and Transplantation (CPNT), Cairo University
Children’s Hospital, Egypt; both groups were compared with a control group of
40 subjects with normal renal function. Serum fetuin-A, IL-1b, IL-23, TNF-α,
circulating soluble intercellular (sICAM-1) and vascular cellular (sVCAM-1)
adhesion molecules were measured by ELISA. Results: Comparing
the hemodialized patients in group II with the non-hemodialized in group I, IL-1b
was significantly lower in group II (p=0.023), whereas, other parameters
showed insignificant decrease (sICAM-1, p=0.223, sVCAM-1, p = 0.209, TNF-α, p =0.059,
IL-23, p =0.339, Fetuin-A, p =0.236). All
inflammatory markers were significantly higher in both patient groups I and II,
compared to their control, except for fetuin-A which showed a significant
decrease. Statistically significant negative linear correlations were found
between fetuin-A and all inflammatory markers among all studied patient groups
and within each group separately.Conclusion: Our data suggest that the
immune cells in hemodialized children are in an activated state which explains
the induced alterations in the assessed immunological markers. An important negative associations between serum fetuin-A and
serum inflammatory markers concentrations were also demonstrated.
[Mona F. Schaalan, Lamiaa N. Hammad, Sahar A. Raouf ,
Maha A. Abo-Shadi and Waleed A. Mohamed.Serum Fetuin-A in Egyptian Pediatrics with Chronic End-stage
Renal Diseases: A Correlation to Vascular Inflammatory Biomarkers. Life Sci J 2013;10(1):1149-1156]
(ISSN: 1097-8135). http://www.lifesciencesite.com.
Keywords: Chronic End-stage Renal Disease (ESRD), Pediatrics, Haemodialysis, Fetuin-A, adhesion molecules, Interleukins.
