Effect of Mon
Effect
of Monosodium Glutamate on Chick Embryo Development
Fatma Al-Qudsi and Anan
Al-Jahdali
Biology Department, Science
Faculty, King AbdulAziz University, Jeddah, Saudi Arabia
Abstract: Monosodium
glutamate (MSG) is a natural neurotransmitter amino acid and a flavoring agent
added to many processed food and used by many housewives in cooking. Fertile
chicken eggs were injected once with (0.75mg MSG/gm. egg weight) in the air
chamber before incubation. Eggs were then incubated under normal incubation
conditions. Embryos were extracted on day 7, 10 and 14 of incubation. Treated
embryos showed different congenital malformations such as growth retardation
and subcutaneous bleeding in 7, 10 and 14 days compared to the controls.
Abdominal hernia was seen in 7 and 10 day treated embryos. Most of the
congenital malformations were seen in 10 day treated chick embryos such as
brain deformation, monophthalmia and beak malformation. Histological study of
the developing liver in the studied ages of the treated embryos showed that
liver seemed to have less cell density and a dilation of venous canals and
blood sinusoid. Fibrosis, bleeding, hemorrhage and congestion were seen in the
central and portal veins. Many cavities appeared in the peripheral liver parts
compared to controls. On the cellular level many cells had a granular
appearance. Also an increase in the number and size of lipid droplets was seen
in the treated sections compared to the controls. pyknotic, karyolisis were
seen in treated hepatocytes Also phagocytic cells were seen in blood sinusoids.
Necrosis was also seen in treated sections. It was concluded that a single low
dose of monosodium glutamate might affect chick embryonic development causing
growth retardation, congenital malformations, and liver degeneration.
[Fatma Al-Qudsi, Anan Al-Jahdali. Effect of
Monosodium Glutamate on Chick Embryo Development. J
Am Sci 2012;8(10):499-509]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 72
Key words: chick embryo, monosodium glutamate, liver, growth
retardation, monophthalmia. Full Text 72
