Effect of Some
Effect of Some Levels from Ginseng, Barley and Carob on
Lipid Profile and Kidney Functions of Rats Fed on High Fructose Diets.
Mohamed M. El-sayd Ali1;
Ashraf A. Abd El-Megeid2 and Riham Abdel-Khalk Abdo Mostafa1,3
1 Nutrition and Food Science Department, Faculty of Home
Economics, Minufiya University, Cairo, Egypt, 2 Nutrition
and Food Science Department, Faculty of Home Economics, Helwan University,
Cairo, Egypt, 3 Clinical Nutrition Department, Faculty of
Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia. [email protected]
Abstract: The
main target of the present investigation is to study the effect of three levels
from ginseng, barley and carob (2.5%, 5% and 7.5%) and their combinations on
biological value, lipid profile and kidney functions and histopathological
examination in kidney of rats fed on high fructose diet. Seventy male Sprague
albino rats divided into two main groups. The first group fed on basal diet as
a (-ve control group), while the second main group fed on high fructose diet
for two weeks. The second main group divided into thirteen subgroups. Subgroups (1, 2&3) fed on high fructose diet (HFD)
containing 2.5%, 5% and 7.5% ginseng, respectively. Subgroups (4, 5&6) fed
on HFD containing 2.5%, 5% and 7.5% barley, respectively. Subgroups (7, 8 & 9) fed on HFD containing 2.5%, 5% and
7.5% carob. Subgroups (10,
11&12) fed on HFD containing 2.5%, 5% and 7.5% combination of (ginseng,
barley and carob).Subgroups (13) fed on HFD only
(control positive group). At the end of the experimental period (4
weeks) rats were fasted over night before sacrificing, blood was collected then
centrifuged to separate the serum. Kidney was removed from each rat, cleaned
and weighted to estimate of kidney weight / body weight percent. Kidney was
examined hestopathologically. The obtained results revealed that, feeding
rats on high fructose diet led to significant increase in (body weight gain %,
kidney weight/body weight %, cholesterol, triglycerides, LDL-c, VLDL-c, uric
acid, urea nitrogen, creatinine) and decreased (food intake and HDL-c). Feeding
rats on high fructose diet with the different levels from ginseng, barley,
carob and their combinations improved all parameters and kidney weight,
especially when used the high level from (barley, ginseng and combination of
ginseng, barley and carob). The histopathological examination in the kidney
confirmed this improvement.
[Mohamed M. El-sayd Ali; Ashraf A. Abd El-Megeid and
Riham Abdel-Khalk Abdo Mostafa. Effect of Some Levels from Ginseng,
Barley and Carob on Lipid Profile and Kidney Functions of Rats Fed on High
Fructose Diets. J Am Sci 2012;8(10):152-162]. (ISSN:
1545-1003). http://www.jofamericanscience.org.23
Key words: ginseng – barley- carob - rats – fructose ––
kidney function – lipid profile – histopathology. Full Text 23
