Expression and
Expression and clinical significance of NF-κB and VEGF-C
in esophageal squamous cell carcinoma
Zheng
Tang, Yongxia Wang, Aihong Yang, Xinlai Qian Yu Wang
1. Department of Forensic
Pathology, Xinxiang Medical University; 2. Department of Pathology, Xinxiang
Medical University; 3. Third Teaching Hospital of Xinxiang Medical University,
Xinxiang, 453003, China; 4. The first people’s hospital of Zhengzhou.
Abstract AIM: To
detect the expression of Nuclear transcription factor-kB(NF-κB) and vascular
endothelial growth factor-C(VEGF-C) protein in esophageal squamous cell
carcinoma (ESCC) and explore their relationship with the prognosis of ESCC. Methods: SP
immunohistochemical method was used to detect the expression of NF-κB and VEGF-C
protein in 124 cases of ESCC and 62 cases of normal esophageal mucosa. Results: The
positive expression rates of NF-κB and VEGF-C protein in specimens of ESCC were
53.2% and 69.4%, in normal esophageal mucosa were 17.7% and 3.2%, respectively.
Both of them had the significant differences between ESCC and normal mucosa (P <
0.05). The positive expression of NF-κB and VEGF-C protein were closely
correlated with the infiltration and lymph node metastasis of ESCC (P <
0.05), but were not correlated with the tumor grade, age or gender of the
patients (P > 0.05). Moreover, the expression of NF-κB protein
was positively correlated with VEGF-C (P<0.05). Conclusion: The
expression of NF-κB and VEGF-C protein is closely correlated with the clinic
pathological characteristics of ESCC. The genes of NF-κB and VEGF-C may play
important roles in the infiltration and metastasis ESCC. United detection of
them may be used as important prognostic predictors in ESCC.
[Zheng Tang , Yongxia Wang ,
Aihong Yang, Xinlai Qian Yu Wang. Expression and clinical significance
of NF-κB and VEGF-C in esophageal squamous cell carcinoma. Life Sci
J 2013;10(1):3044-3047] (ISSN:1097-8135).http://www.lifesciencesite.com.
Key words: esophageal squamous cell carcinoma; nuclear transcription factor-κB; vascular endothelial growth factor-C; invasion; metastasis; prognosis.
