Histopathologic
Histopathological Changes in Some Organs of Male Rats Fed on Genetically Modified Corn (Ajeeb YG)
El-Shamei1, Z. S., Gab-Alla1, A.A., Shatta1, A. A, Moussa2, E. A. and Rayan1, A. M.
1 Food Technology Department, Faculty of Agriculture, 2 Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. [email protected]
Abstract : Ajeeb YG is a genetically modified (GM) insect resistant corn produced by incorporated the MON 810 (Monsanto) borer resistance trait in the best corn germplasm Ajeeb. The safety of Ajeeb YG corn was assessed by comparison of toxicology response variables in rats consuming diets containing Ajeeb YG with those containing Ajeeb corn grains. Corn grains from Ajeeb YG or Ajeeb were incorborated into rodent diets at 30% concentrations administered to rats (n= 10/group) for 91 days. An additional negative control group of rats (n= 10/group) were fed AIN93G diets. Rats fed on GM corn showed histopathological changes. Liver displayed cytoplasmic vacuolation of centrolobular hepatocytes and fatty degeneration of hepatocytes. Kidneys showed congestion of renal blood vessels and cystic dilatation of renal tubules. Testes revealed necrosis and desquamation of spermatogoneal germ cells lining seminiferous tubules. Spleen showed slight lymphocytic depletion and splenic congestion. Small intestine showed hyperplasia, hyperactivation of mucous secretory glands and necrosis of intestinal villi were detected. Due to these observations, we suggest that the risk of GM crops cannot be ignored and deserves further investigations in order to identify possible long-term effects, if any, of GM food consumption that might help in the post market surveillance.
[El-Shamei, Z. S., Gab-Alla, A.A., Shatta, A. A, Moussa, E. A. and Rayan, A. M. Histopathological Changes in Some Organs of Male Rats Fed on Genetically Modified Corn (Ajeeb YG)] Journal of American Science 2012;8(10): 684-696]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 93
Key words: genetically modified corn; histopathology; rats; liver, kidney; small intestine Full Text 93
