Pro- and anti-i
Pro- and anti-inflammatory cytokines in uncomplicated
type 2 diabetes patients
Laila Damanhouri
Medical Laboratory Technology
Department, Faculty of Applied Medical Sciences, King Abdulaziz University,
Jeddah, Saudi Arabia. [email protected]
Abstract: Background. Role of systemic pro- and anti-inflammatory cytokines are
associated with type 2 diabetes mellitus (T2DM) in adults is unclear. In this
cross section study, we compared cytokine concentrations in patients with T2DM
and healthy individuals to test the hypothesis that differences of cytokine
concentrations between them are attributable to diabetes and metabolic control. Methods. The
pro-inflammatory cytokine as interferon gamma (IFN-γ) and anti-inflammatory
cytokines as adiponectin and interleukin (IL)-10 were measured in 50
participants with T2DM and 70 healthy controls using ELISA kits. Results. IFN-γ
was significantly increased while adiponectin and IL-10 were significantly
decreased in T2DM than healthy controls (P <0.0001). In T2DM
patients, negative correlations were found between fasting blood glucose with
adiponectin (r= -0.293, P <0.039) and IFN-γ with IL-10 (r=
-0.320, P <0.023). BMI was positively correlated with IFN-γ
(r= 0.723, P <0.0001) and glycozylated hemoglobin (r=0.399, P<0.016). Conclusion. T2DM
showed elevated serum levels of inflammatory cytokine IFN-γ and decrease serum levels of anti-inflammatory
cytokines (adiponectin and IL-10) and negative association between
anti-inflammatory cytokine and blood glucose levels indicated importance of
inflammation in pathogenesis of T2DM. The
hypothesis that T2DM is inflammatory disease opens new clinical perspectives
for diagnosis and treatment but still requires further investigation.
[Laila Damanhouri. Pro- and anti-inflammatory cytokines in uncomplicated
type 2 diabetes patients. J Am Sci 2012;8(10):466-472]. (ISSN:
1545-1003). http://www.jofamericanscience.org. 68
Keywords: Adiponectin.
Glycozylated hemoglobin. Interleukin-10. Interferon gamma.
Type 2 diabetes in adult. Full Text 68
