Reactions of 5-
Reactions of 5-Bromo-4,6-Dimethyl-2-Thioxo-1,2- Dihydropyridine -3- Carbonitrile with Organophosphorus Reagents
Hoda A. Abdel – Malek1*, Marwa. S. Salem2, and Leila S. Boulos1
1Department of Organometallic and Organometalloid Chemistry, National Research Centre, El – Behoos St., P.O. 12622, Dokki, Cairo, Egypt
2Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya , Cairo, Egypt. *[email protected]
Abstract: The reaction of 5-bromo-4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (1) with phosphorus ylides2a,b afforded the new phosphonium ylides 7a,b. Wittig – Honer reagent 3 reacts with 1 to give the olefinic product 8. On the other hand, the dimeric compound 9 and the alkylated products 10, 11 were isolated from the reaction of 1 with dialkyl phosphite 4, trialkyl phosphite 5 and tris(dimethylamino) phosphine 6. Possible reaction mechanisms are considered, and the structural assignments are based on analytical and spectroscopic evidence.
[Hoda A. Abdel – Malek, Marwa. S. Salem, and Leila S. Boulos. Reactions of 5-Bromo-4,6-Dimethyl-2-Thioxo-1,2- Dihydropyridine -3- Carbonitrile with Organophosphorus Reagents. Life Sci J 2012;9(1):695-700]. (ISSN: 1097-8135).http://www.lifesciencesite.com. 100
Keywords: Phosphorus ylides, Wittig-Horner reagent, phosphites, dihydropyridines, nicotinonitriles. Full Text 100
