The Protective
The
Protective Effect of Ginger (Zingiber Officinale) Against Adriamycin-
Induced Hepatotoxicity in Rats: Histological
Study
Mohamed Atif Ahmed Said
Ahmed
Anatomy Department, College
of Medicine, Zagazig University, Egypt
Abstract: Aim:
The present study aimed to show the histopathological and ultrastructural
changes occurred in the rat liver post-application of adriamycin and to
evaluate the possible protection of ginger against adriamycin induced hepatic
toxicity. Material And Methods: Animals were divided into four groups. The
first group was given saline orally. The second group was given ginger extract
orally with a single daily dose 250 mg/kg b.wt. for two weeks. The third group
was treated with adriamycin in six intraperitoneal injections (each containing
2.5 mg/kg/b.wt) over a period of two weeks. The fourth group was treated with
adriamycin at the same dose level as those of group III and by oral
administration of ginger extract (250 mg/kg/b.wt) daily for two weeks. Livers
specimens from all groups were examined by light and electron microscopies.
Results: Adriamycin treated group revealed destruction of the hepatic cords,
cytoplasmic vacuolization, cellular degeneration, pyknotic and
atrophic nuclei, damaged mitochondria and accumulation of lipid droplets in the
hepatocytes and deposition of a collagen-like fibrous material in the blood
sinusoids and space of Disse with dilated intercellular spaces. Dilated blood
sinusoids and dilated bile canaliculi with atrophy of its microvilli were also
noticed. Damaged Kupffer cells with vacuoles were prominent. The hepatotoxic
effect of adriamycin was ameliorated with partial disappearance of pathological
hepatic damage when treatment was combined with ginger. The results of the
present work indicated that ginger had protective effect against liver damage
induced by adriamycin.Conclusion: The present results provide in vivo evidence
of direct chemotherapeutic hepatotoxicity caused by adriamycin. Appropriate
protective measures as ginger must be applied with anticancer treatment for
improving liver structure. The results can further suggest the possible use of
ginger against oxidative stress induced organ toxicities.
[Mohamed
Atif Ahmed Said Ahmed. The Protective Effect of Ginger (Zingiber
Officinale) Against Adriamycin- Induced Hepatotoxicity in Rats: Histological Study. Life Sci J 2013;10(1):1412-1422]
(ISSN:1097-8135). http://www.lifesciencesite.com.
Key words: Ginger – adriamycin – hepatotoxicity – protection – histology- ultrastructure - liver.
