Design, Formulat
Design, Formulation and Evaluation of
Transdermal Ketoprfen Gel
Ahmed M. Samy1,
Mamdouh M. Ghorab2, Shadeed G. Shadeed 2 and
Eman A. Mazyed3
1Department of Pharmaceutics and Industrial Pharmacy,
Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
2Department of Pharmaceutics, Faculty of Pharmacy, Suez
Canal University, Ismailia, Egypt
3Department of Pharmaceutics, Faculty of Pharmacy and
Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt
Abstract: The
aim of this study was to develop Ketoprofen (KPF) gel for tansdermal delivery
that could enhance dissolution and permeability of KPF. KPF gels were prepared
using Carboxy methyl cellulose (CMC), hydroxyl
propyl methyl cellulose (HPMC) and methyl cellulose (MC) with and without
permeation enhancers (Tween 80 and Oleic acid). The effect of the
employed gel bases and permeation enhancers on the in vitro release,
permeation and viscosity of gel formulae was tested. The results showed that
both polymers and permeation enhancers affect release, permeation and
rheological properties of KPF gel. Formula containing 5% MC and 5 % Tween80
showed the best in-vitro release (98.22% ±1.18), the best permeation through
rat skin (96.39% ±3.23) and the lowest viscosity.
[Ahmed M. Samy, Mamdouh M. Ghorab, Shadeed G.
Shadeed and Eman A. Mazyed. Design, Formulation and
Evaluation of Transdermal Ketoprfen Gel. J Am Sci 2013;9(3):237-242].
(ISSN: 1545-1003). http://www.jofamericanscience.org. 32
Keywords: Ketoprofen, transdermal, permeation, methyl
cellulose, Tween80 Full Text 32
