Effect of Clomip
Effect of Clomiphene Citrate on the Fallopian Tube of
Rats. Histological Considerations and Clinical Implications
Metwally Abd-El-Bary Mansoor
Anatomy Department, Faculty
of Medicine, Zagazig University. [email protected]
Abstract: Background: Fallopian tube is a dynamic, steroid responsive
tissue that facilitates fertilization of the gamete and early embryo transport.
Clomiphene citrate is considered the first line therapy for induction of
ovulation in women with anovulatory infertility. There is marked increase in
the rate of ectopic tubal pregnancy with clomiphene citrate therapy. Objective: To
clarify the histological changes in the tubal mucosa that accompany clomiphene
citrate therapy and may predispose to ectopic tubal pregnancy. Material
and Methods:Twenty prepubertal female rats were used, they were divided
into control group and another group treated with intraperitoneal injections of
10 mg/kg body weight/day of clomiphene citrate for 6 consecutive days. Results:Hypertrophy
and hyperplasia of the tubal epithelium with marked ciliogenesis. Marked
disturbance of tubal mucosa with shedding of parts of tubal mucosa and mucosal
folds into the lumen of the tube. Accumulation of structureless masses in the
lumen of the tube. The changes were seen in the tubal ampulla as well as the
isthmus.Conclusion: Mucosal disturbance and shedding, epithelial
hyperplasia and hypertrophy, luminal masses of shedded epithelium and
structurless tissues and disturbance in the function of both epithelial and
secretory cells. All the preceeding features may hinder the movement of
fertilized ovum and consequently increase the chance for occurrence of ectopic
tubal pregnancy.
[Metwally Abd-El-Bary Mansoor. Effect of
Clomiphene Citrate on the Fallopian Tube of Rats. Histological Considerations
and Clinical Implications. J Am Sci 2013;9(6):197-202].
(ISSN: 1545-1003).http://www.jofamericanscience.org. 23
Key words: Fallopian tube, mucosa, epithelium, clomiphene
citrate, histological considerations, rats. Full Text 23
