Experimental Com
Experimental Comparative Study
of the Possible Effect of Panax Ginseng and Fish Code Oil against Acetaminophen Induced Hepatotoxicity
Wesam
A.ElslamA.Elwahab1, Heba Gamal Abd El-Aziz2 and Mona
A.A. Arafa3
1 Department
of Forensic Medicine and Clinical Toxicology - Faculty of Medicine -Al-Azhar
University
2
Department of Biochemistry- Faculty of Pharmacy-Al-Azhar University
3
Department of Anatomy- Faculty of Medicine -Al-Azhar University
Abstract: Background: Hepatic damage due to drugs,
xenobiotics and environmental pollutants has been a serious concern worldwide.
Acetaminophen is widely used as an analgesic and antipyretic drug, which can
cause hepatic injury when given in high doses. Panax ginseng (Chinese
medicinal herb) and Fish code oil with antioxidant properties would attenuate
the intensity of the oxidative stress often involved in the pathogenesis of
various diseases and have been studied in a variety of clinical conditions and
found to protect against cellular damage. The objective of the present study
was to study and compare the possible effect of ginseng and fish code oil
against acetaminophen induced hepatotoxicity.Methods:36 rats were divided into
six equal groups (n = 6): first group (healthy control), second group (positive
control group), they were given a single oral dose of acetaminophen (500
mg/kg), the third and fourth groups were given Panax ginseng (300
mg/kg) and fish oil (4 ml/kg) as protection for 7 consecutive days prior to
single oral dose of acetaminophen (500 mg/Kg), the fifth and sixth groups were
first taken single oral dose of acetaminophen (500 mg/Kg) and after 3 days the
animals were treated with ginseng and fish code oil for 7 days (300mg/Kg and 4
ml/Kg, respectively). Blood was taken from the orbital sinus of the rats for
biochemical tests serum transaminases (ALT, AST), Alkaline phosphatase (ALP),
Total protein (T.P) and Albumin (Alb.) and at the same time liver was removed
and kept in 10% formalin solution for histological analysis. All histological sections were subjected to
morphometric study, pathological evaluation followed by statistical analysis.Results: The results showed that the acute elevation of
serum ALT,AST, ALP and the acute reduction of T.P and Alb. due to acetaminophen
induced hepatotoxicity were significantly corrected in the groups receiving Panax
ginseng and fish code oil. Necrosis of liver significantly decreased
according to histopathologic observation, and that fish code oil was
significantly more effective against acetaminophen induced hepatotoxicity when
compared with ginseng.Conclusion: It is concluded that both Panax
ginseng and fishcode oil have protective and treating effect on
hepatotoxicity induced by acetaminophen and that fish code oil has better
effect than Panax ginseng.
[Wesam A. Elslam
A. Elwahab, Heba Gamal Abd El-Aziz and Mona A.A. Arafa. Experimental
Comparative Study of the Possible Effect of Fish Code Oil and Panax
Ginseng against Acetaminophen Induced Hepatotoxicity. J Am Sci 2013;9(6):234-244].
(ISSN: 1545-1003). http://www.jofamericanscience.org. 27
Key
words: acetaminophen, ginseng, fish code oil, hepatotoxicity Full Text 27
