Expression and si
Expression
and significance of Caspase-8 in non-small cell lung cancer(NSCLC)
Zhenfeng Zong, Jun Yuan, Bo
Yang, Fengli Sun, Mingming Ren
Department of Thoracic
Surgery, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China
Email: [email protected]
Abstract: Objective: RCAS1, Caspase-8 expression in non-small cell lung
cancer and its significance. Methods: the soluble RCAS1 in our
hospital between February 2009 to February 2010, included 40 patients with
non-small cell lung cancer, the expression of caspase-8 protein taken
immunohistochemistry method were measured, and select the normal lung tissue
RCAS1 Caspase-8 protein expression compared. Results: There are two
comparative analysis, the positive expression rate of tumor patients RCAS1
RCAS1 positive expression rate was significantly higher than the two sets of
data was statistically significant (P <0.05); Oncology Group of Caspase-8
positive the expression rate Caspase-8 positive expression rate was
significantly lower than the control group data in two groups was statistically
significant (P <0.05). Correlation analysis of protein expression in
non-small cell lung cancer, the soluble RCAS1 Caspase-8 expression in non-small
cell lung cancer negative correlation (r = -0.121, P <0.05). Conclusion:
the soluble RCAS1 Caspase-8 protein in non-small cell lung cancer in the
abnormal expression of the disease can be used as an important diagnostic
marker, has important applications in clinical.
[Zhenfeng Zong, Jun Yuan, Bo Yang, Fengli Sun, Mingming Ren. Expression and significance of Caspase-8 in non-small cell lung cancer (NSCLC). Life Sci J 2013:10(1):3165-3167]. (ISSN: 1097-8135).http://www.lifesciencesite.com.
Key words: non-small cell lung cancer; The RCAS1; Caspase-8; protein expression.
