Losartan versus E
Losartan
versus Endoscopic Variceal Ligation (EVL) In Primary Prophylaxis of Variceal
Bleeding in Egyptian Cirrhotic Patients: prospective study
Mohamed S.
Zakaria, Mohammad S. Abdelbary, Khaled S. Zakaria, Sherif H. Mahmoud Ahmad M.
Khairy
Endemic Medicine
and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract: Introduction: esophageal varices (OV) is one of the major
complications of portal hypertension in cirrhotic patients, bleeding form
varices can be prevented using EVL, moreover blocking the activity of AT II
(angiotensin II receptors) may have beneficial effects in lowering portal
pressure. This study aimed at assessing Losartan versus EVBL in primary
prophylaxis of variceal hemorrhage. Patients & Methods: 40
cirrhotic patients with esophageal varices of grade III to IV were classified
into two groups, group I n=20 received Losartan therapy while group II n=20
received EVBL sessions, then patients were followed up after therapy for three
months. Results: signs of impending variceal rupture disappeared in
both groups with improvement in the grade of varices to become grade I in 100%
in group II but only 17.6% in group I, Congestive gastropathy and ascites
grades were improved in group I but deteriorated in group II. Conclusion: Both
Losartan & EVBL are effective prophylactic to variceal hemorrhage in
cirrhotic patients but Losartan was associated with much less complications.
[Mohamed S. Zakaria, Mohammad S.
Abdelbary, Khaled S. Zakaria, Sherif H. Mahmoud Ahmad M. Khai.Losartan versus Endoscopic Variceal Ligation (EVL) In
Primary Prophylaxis of Variceal Bleeding in Egyptian Cirrhotic Patients:
prospective study. J Am Sci 2013;9(6):38-42]. (ISSN: 1545-1003).http://www.jofamericanscience.org.
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Keyword: Losartan, EVBL, congestive gastropathy, ascites,
variceal hemorrhage. Full Text 5
