Misoprostol versu
Misoprostol versus Surgical Intervention for Incomplete Abortion in Iran
Samie Karimi1, Minoo Rajaei2, Mahboobeh Nasrollahi3 , Yaghoub Hamedi2, Kamelia Madani3, Esmaeil Aliabadi4
1. Assistant professor, Gynecologic Oncology Fellowship, Hormozgan University of Medical Sciences (HUMS), BandarAbbas, Hormozgan, Iran
2. Associate professor, Fertility and Infertility Research Center, Hormozgan University of Medical Sciences (HUMS), BandarAbbas, Hormozgan, Iran
3. Resident of Obstetrics and Gynecology, Fertility and Infertility Research Center, Hormozgan University of Medical Sciences (HUMS), BandarAbbas, Hormozgan, Iran
4. Infectious and Tropical Disease Research Center, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran
Abstract: Introduction: Incomplete abortion is still one of the most important causes of maternal mortality and morbidity in developing countries. Surgical treatment is the standard treatment for incomplete abortion for years, but Misoprostol usage is recently noted and is safe, effective, and low cost treatment especially in areas with low resources. The aim of this study was to compare the efficacy and safety of misoprostol and surgical treatment in incomplete abortion. Methods: In this randomized clinical trial study 150 women with incomplete abortion that referred to Shariati hospital of Bandar-Abbas were evaluated. The patients were divided in 2 groups randomly. Group A received 600 mg misoprostol and D&C was perform for Group B. after 7 days, patients were reevaluated. Successful treatment approved by ultrasonography. Data were analyzed by SPSS-16, descriptive study, Chi-square and T-test. Significant level was set as P<0.05. Results: The mean age of patients was 27.74 ± 5.84 years. Two groups were not different in age, gestational age, and hemoglobin (P>0.05). The success rate after treatment in surgery group (96%) significantly higher than the misoprostol (10.66%) group (P=0.000). The patients who had failure of treatment with 2 course of misoprostol were underwent to D&C surgery and all of them were successful. Conclusion: The results of this study and other study indicate, although the success rate of misoprostol was lower than surgery, but use of misoprostol for incomplete abortion in women is safe and could prevent uterine rupture and unnecessary surgeries, particularly in women who anesthesia or surgery is contraindicated. Large randomized trials focusing on patients with incomplete abortion are needed to confirm these results.
[Karimi S, Rajaei M, Nasrollahi M, Hamedi Y, Madani K, Aliabadi E. Misoprostol versus Surgical Intervention for Incomplete Abortion in Iran. Life Sci J 2013;10(7s): 351-354] (ISSN:1097-8135). http://www.lifesciencesite.com. 56
Keywords: Incomplete abortion, Misoprostol, D&C surgery
