Rheumatoid Arthri
Rheumatoid Arthritis and Stroke: is
Homocysteine a Linking Factor?
Yusheng1 Li;
Hui Yu2; Avinash Chandra1; Haili Wang; Yuming Xu1'
1. Department
of Neurology, All the authors are from The First Affiliated Hospital of
Zhengzhou University, Zhengzhou, Henan, China
2. Department
of Radiation Oncology, All the authors are from The First Affiliated
Hospital of Zhengzhou University, Zhengzhou, Henan, China
Email- [email protected]
Abstract: Ever
since increase in homocyseteine (hcy) level termed as hyperhomocysteinemia (
hhcy) has been recognized as one of causal factors for an independent factor
for the atherothromobosis and endovascular injury, it has become an element of
great interest of research. Homocysteine (hcy) has close association
(between hcy and different diseases) particularly in rheumatoid arthritis (RA)
and in cardio and cerebro-vascular diseases. The capability of hcy to the
vascular damage and structurally modifying specific proteins, resulting in
formation of neo-antigens may also be a triggering factor of autoimmune
reactions and thus hcy has probability to present itself as an initiating
factor in autoimmune disease like RA. These all circumstances point towards
potentially relevant role of hcy in the onset of specific autoimmune disease.
Hcy causes or plays a role in the progression of the associated cardiovascular
and cerebrovascular damage through its inflammatory property. Immuno-inflammatory
activation may contribute to the increase in hcy level which in turn may add up
to the injury of the specific organ in specific diseases (like vessel injury in
cardio and cerebrovascular disease, synovial tissue in RA). This
bi-directional link appears to connect hcy and the auto-immune disease
(immuno-inflammatory activation). In this review we have tried to present
the potential relation of hcy as a common linking factor between stroke and
rheumatic arthritis, through its bi-directional property. Through this current
opinion we have tried to put forth our opinion that hcy is one of the common
causal factors in stroke well as in rheumatoid arthritis. This carries an
interesting clinical importance in control and prevention of these two diseases
of different entity at a common point.
[YushengLi,Hui Yu, Avinash Chandra, Haili
Wang,Yuming Xu. Current opinion
Rheumatoid Arthritis and Stroke: is Homocysteine a Linking Factor? Life Sci J 2013:10(1):3121-3127].
(ISSN: 1097-8135).http://www.lifesciencesite.com.
Keywords: Homocysteine, Inflammation, Autoimmune disease, Stroke, Rheumatoid Arthritis.
