Biological Value o
Biological Value of Annexin AV and
Anti-annexin Antibodies in patients with
systemic lupus erythematosus and Anti-phospholipid (Hughes) syndrome
Eman M. I. Youssef¹, Eman
El-Shohat¹, Eman S.M.Baiomy¹, Naglaa F. Abdel Halim² and Nashwa El-Khouly³
Departments of ¹Medical
Biochemistry, ²Microbiology and Immunology and ³Internal Medicine, Faculty of
Medicine (Girls), Al-Azhar University. [email protected]
Abstract: Systemic
lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease.
Anti-phospholipid (APL) antibodies arc
frequently found in SLE patients. Fifty percent of Anti-phospholipid syndrome(APS) is secondary to SLE. Annexin AV (ANX AV) exhibits anti-coagulant properties, but aPL antibodies
formed against it interfere with its function. The study aimed to investigate
whether anti-annexin AV (aANX
AV) antibodies (lgM/IgG) or ANX AV plasma level is related to pathophysiology of
SLEor APS. Measurement of aANX
AVantibodies (lgM/G) and ANX
AV plasma level by Enzyme Linked Immunosorbent Assay (ELISA) in 40
patients divided into two groups SLE and APS and 20 healthy control of matched
age. Anti-ANX AV lgM antibodies were significantly
associated with APS; this was revealed when we compared patients with Primary
APS and Secondary APS to the control group. There was significant difference in ANX AV plasma level when
compared SLE to Primary APS and Secondary to Primary APS. ANX AV plasma levels were not affected by the presence of Anti ANV lg M/G.
Conclusively, it could be suggested that theANX AV plasma level may contribute to
susceptibility (low levels) or the protection (high levels) againsthypercoagulability in APS patient. It may also
reflect the severity of SLE. In addition, ANX AV plasma levels are not affected by the presence of Anti ANV lgM/G. ANX AV plasma levels may be an
import tool in diagnosis and also target for treatment.
[Eman M. I. Youssef, Eman El-Shohat, Eman S. M.
Baiomy, Naglaa F. Abdel Halim and Nashwa El-Khouly.Biological Value of
Annexin AV and Anti-annexin Antibodies in
patients with systemic lupus erythematosus and Anti-phospholipid (Hughes)
syndrome. Life Sci J 2013;10(1):1144-1148]
(ISSN:1097-8135).http://www.lifesciencesite.com.
Key words: Systemic lupus erythematosus, Anti-phospholipid syndrome, Anti-phospholipid antibodies, Anti-ANX AV antibodies (lgM/IgG), ANX AV plasma level.
