Diagnostic value o
Diagnostic value of ESR, CRP, and PLT in comparison to
PCT and C3 in septic ICU cases
Reza Imani Rastabi 1*, Ghorbanali
Shahabi2 and Ali Fazel3
1Department of Infectious & Tropical Diseases,
Shahrekord University of Medical Sciences, Shahrekord, Iran
2Department of Immunology, Shahrekord University of
Medical Sciences, Shahrekord, Iran.
3Shahrekord University of Medical Sciences, Shahrekord,
Iran
*Corresponding author: Reza Imani Rastabi
Kashani Street, Shahrekord
University of Medical Sciences, Shahrekord, Iran
Tel: 98-913-3815531; Fax: 98
381 2221669; Email: [email protected]
Abstract: Sepsis is one of
the most common reasons worldwide for death among intensive care unit
patients because of diagnostic procedures'
limitations. Despite new supportive treatments and administration of
high potent antibiotics, sepsis remains fatal and reduces survivors' life
quality. To measure Procalcitonin (PCT) and Complement C3 (C3) and their
association with Blood Sedimentation (ESR), C-Reactive Protein (CRP), and
Leukocytes (WBC) in suspected sepsis patients in Intensive Care Unit (ICU), and
use changes in ESR, CRP, and WBC as simple and less expensive tests to diagnose
and/or follow up sepsis patients. For this descriptive analytical study, 30
patients with suspected sepsis at ICU were enrolled. ESR, CRP, PLT, and WBC
measurements were performed in three stages: admission time (pre-sepsis), in
case of onset of possible sepsis indications (peri- sepsis), and prior to
discharge (post-sepsis). Serum level of PCT was measured by
immunochromatography and C3 determined by SRID. The data was analyzed by
repeated measure and Pearson correlation coefficient (SPSS 11). ESR, CRP, PLT,
and WBC in peri-sepsis were significantly higher than those in pre- and post
sepsis (p <0.05). Comparing PCT mean level in peri- and
post-sepsis (lowest level) showed a significant difference, while no
significant difference was seen between pre- and peri sepsis (p<0.05).
C3 biomarker was also significantly higher in peri-sepsis than pre- and post
sepsis (p <0.05). Although changes in PCT and C3 have a high
diagnostic value in early stages of sepsis and are used as guides for
antibiotic therapy in suspected sepsis cases, regarding the significant
difference in ESR, CRP, and WBC in peri-sepsis compared to pre- and post-sepsis
in our study, these tests could be offered as simpler and less expensive tests,
having moderate diagnostic value for the diagnosis of sepsis on ICU admission.
[Reza Imani Rastabi, Ghorbanali
Shahabi and Ali Fazel. Diagnostic
value of ESR, CRP, and PLT in comparison to PCT and C3 in septic ICU cases. Life
Sci J 2013;10(4s):215-220]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 32
Keywords: Sepsis, Intensive Care Units, Procalcitonin,
Blood Sedimentation, C-Reactive Protein, Leukocytes, Complement C3
