Dual effect of cur
Dual effect of curcumin and methotrexate treatment on
various organs in collagen-induced arthritis in rats
Elshaimaa M.Ibrahim1 ,
Abeer M. badr 1, Hiba Sibaii 2, Amany S.
E.El-Wakkad 2, Somaya El-Deeb.1
1 Zoology Department, Faculty of Science, Cairo
University, Egypt; 2 National Research Center, Dokki,
Cairo, Egypt. Corresponding author: [email protected]
Abstract: Objective:To evaluate the effect of methotrexate and curcumin
administration on various internal organs in collagen-induced arthritis in
rats. Material and methods: Animals were divided into 6
groups, 10 rats each. Group I: Normal control, Group II was
injected with DMSO, Group III arthritic rats, Group IV arthritic rats received
methotrexate (MTX) (1 mg/ Kg, i.p) once a week and Group V arthritic rats
treated with curcumin (100 mg/ Kg, i.p) thrice a week. Group VI was treated
with MTX (1 mg/ Kg, i.p) once a week and after 30 min received curcumin (100
mg/ Kg, i.p) thrice a week. Rats were sacrificed and thymus, spleen, liver,
lung and kidney were collected for histopathological evaluation. Results: General
improvement in examined organs from arthritic rats treated with both MTX and curcumin
as compared with other groups. The combination of both MTX and curcumin
restored the normal structure of the examined organs. Conclusion: The
study showed an effective anti-arthritic action with the combination of MTX and
curcumin.
[Elshaimaa M.Ibrahim, Abeer M. badr, Hiba Sibaii,
Amany S. E.El-Wakkad, Somaya El-Deeb. Dual effect of curcumin and
methotrexate treatment on various organs in collagen-induced arthritis in rats. J
Am Sci 2012;8(10):447-454]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 65
Key
words: methotrexate ,
curcumin, arthritis, histopathological investigation Full Text 65
