Effect of parenter
Effect of parenterally
Acetaminophen on the attenuation of post-operative pain subsequent Colectomy
1Eilyad
Issabeagloo, 2Babak Abri Aghdam, 3Ali Rezaei
1- Department of
Pharmacology, Medical Sciences Faculty, Tabriz branch, Islamic Azad
University, Tabriz, Iran.
2- Department of special surgery, Medical Sciences Faculty,
Tabriz branch, Islamic Azad University, Tabriz, Iran.
3- Department
of surgery, Faculty of veterinary medicine, Tabriz branch, Islamic Azad
University, Tabriz, Iran.
Abstract: Introduction: Analgesic efficacy of parenterally acetaminophen is
variable in different surgical procedures. Little data is available on its
efficacy in Colectomy. Intravenous Acetaminophen is a useful drug in
treating postoperative pains and could be used alone or in combination with
other drugs. Current study conducted this prospective, randomized, double blind
study to evaluate and compare the efficacy acetaminophen with morphine in
Colectomy surgery over a 24 hour period. Methods: In a clinical trial, 79
patients candidate for elective lumbar Colectomy were randomly put into groups receiving Acetaminophen (40 patients) or placebo (39
patients). In group one, 1 gr I.V.Acetaminophen infusion
started 15 minutes before the end of
surgery. Group 2 received 100 ml NaCl 0.9% in the same period. Pain scores were
assessed at relaxation with VAS (visual analogue scale) at 0 (after awakening),
5, 10, 15 and 24 hours. Morphine use (according to patient's will due to pain)
was recorded in 24 hours. Results: Acetaminophen group had significantly lower mean VAS
(less sever pain) than placebo group after recovery (5.73±1.89 versus
6.85±2.11, p=0.004), 5 hours later (5.34±2.03 versus 7.67±1.9, p=0.01), 10
hours later (4.81±1.29 versus 5.71±1.31, p=0.02), 15 hours later (4.11±1.05
versus 4.67±1.61, p=0.02) and 24 hours later (2.61±1.31 versus 3.57±1.41, p=0.01).
Morphine requirement in different periods was lower in Acetaminophen group than
placebo which had no significant differences. Mean cumulative morphine use in
24 hours in paracetamol group (5.89±2.79 mg) was lower than placebo group
(8.48±3.51 mg), however the difference was not significant. Conclusion: Results of current study showed that
intravenousAcetaminophen is effective in
reducing postoperative pain severity, but do not reduces need for morphine use.
[Eilyad
Issabeagloo, Babak Abri Aghdam, Ali Rezaei. Evaluation
of effect of Acetaminophen on the lessen of post operative pain due to
Colectomy in parenterally administration. Life Sci J 2013;10(4s):308-313]
(ISSN:1097-8135).http://www.lifesciencesite.com. 45
Keywords: Colectomy;
Acetaminophen; morphine; Postoperative pain.
