Electrogastrograph
Electrogastrographic
(EGG) and Gastric Emptying Changes in Patients with Duodenal Ulcer .The Effect
of H. Pylori Eradication
Samia A. Abdo1,
HishamS. Abdel Fattah2, Uomna Kamel3
1Gastroenterology unit, Faculty of Medicine, Ain shams
University, Cairo, Egypt
2Faculty of Medicine, Misr University For Science And
Technology
3Faculty of Medicine, 6 October University , Cairo,
Egypt
Abstract: Helicobacter pylori infection
and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are now generally
accepted as critical factors in the pathogenesis of peptic ulcer (PU). Helicobacter
pylori(H. Pylori) infection is associated with over 90% of duodenal
ulcer. Helicobacter Pylori infection may result in several
alternation of gastro-duodenal physiology. Aim of the work: was to
study the possible gastric myo-electrical activity changes in patients with H.
Pyloriassociated duodenal ulcer and their relation to gastric emptying, as
well as the effect of H. Pylorieradication on such changes. Patients
and methods: 60 subjects were enrolled in this study and classified
into three groups: Group I: Twenty patients with H. Pyloriinfection
associated with duodenal ulcer Group II: Twenty patients with H. Pylorinegative
duodenal ulcer. Grouplll: Twenty age and sex matched "healthy"
asymptomatic volunteers; ten positive and (llla) ten negative (lllb) for H.
Pylori. For all patients; complete history and physical examination, upper
endoscopy and pyloric antral biopsy for H. Pyloridetection,
abdominal ultrasound, and electro-gastrogram were performed. Results: in
group I patients mean of power ratio (PR) was lower than that of group IIIa
(1.42±0.74 versus 2.94±1.9 (P<0.01), while, gastric emptying parameters
showed insignificant difference. No significant difference was found between
group II and group IIIb as regards EGG parameters, while full time and ½
empting time in-group II was significant by lower than group IIIb. (13±2.8min,
15.7±2.8min. respectively P<0.05, and 4.89±2.2min, versus
6.7±2.48min for ½ empting time P<0.05). After eradication
therapy 87% of our patients became negative for H. Pylori, EGG
repeated for group 1 patients after eradication. The mean of % power at rest,
The mean of %CPM at meal, and The mean of PR was significantly lower before
than after treatment(P<0.05, <0.05. &<0.01). The mean of
power at rest of DF was statistically significant higher before than after
treatment P<0.01. Mean of 1/2 in-group I patients was higher before
than after eradication therapy). Conclusion: Helicobacter
pylori infection can affect gastric motility, especially in duodenal
ulcer infected patients. Eradication therapy improved not only EGG
abnormalities but also aids in restoration of abnormal
water gastric emptying.
[Samia A. Abdo, HishamS. Abdel Fattah and Uomna Kamel. Electrogastrographic (EGG) and
Gastric Emptying Changes in Patients with Duodenal Ulcer. The Effect of H.
Pylori Eradication. Life
Sci. J2013;10(1):3081-3088]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
Keywords: Electrogastrography (EGG), gastric motility, Helicobacter Pylori, duodenal ulcer.
