Late histopatholog
Late
histopathological findings in the thoracic irradiation: A preliminary study in the animal model
A. Takavar1,
B. Minaei1, GH. Hadadi2, S. Khoei1, S. Refahi1,3*,
Z. Behrouzkia4, M. Pourissa5, G. Ghamami1
1Tehran University of Medical Sciences, Tehran, Iran.
2Fasa University of Medical Sciences, Fasa, Iran.
3Ardebil University of Medical Sciences, Ardebil, Iran.
4Urmia University of Medical Sciences, Urmia, Iran.
5Neurosciences research Center, Tabriz University
of Medical Sciences, Tabriz, Iran.
Corresponding Author: [email protected]
Abstract: To
investigate late histopathological alterations in rat lung cells following
single-dose of irradiation. Methods and materials: The
thoracic cage of entire lung of Wistar rats was exposed to 17 Gy 60Co
gamma rays. The animals were sacrificed at 32 weeks after irradiation. The
lungs were dissected and blinded histopathological evaluation was performed.Results: When
the lungs were removed at 32 weeks after whole thoracic irradiation,
histopathologically inflammation and mononuclear infiltrate in the
interstitium, Intraalveolar hemorrhages, dilatation in the alveolar space with
alterations of the alveolar wall, congestion of the dilated vessels, foam and
dust cells and superimposed collagen were noted in all animals.Conclusion:
At the end of the histological examination, it was seen that all of the animals
had severe superimposed collagen and a large fibrous area. We conclude that, in
the rat lung model with single dose of 17 Gy, the most interesting finding in
this study was in the expression of late fibrosis.
[A. Takavar, B. Minaei, GH. Hadadi, S. Khoei, S.
Refahi, Z. Behrouzkia, M. Pourissa, G. Ghamami. Late histopathological findings
in the thoracic irradiation: A preliminary study in the animal model. Life Sci J 2013;10(7s):583-585] (ISSN:1097-8135). http://www.lifesciencesite.com. 92
Keywords: Thoracic irradiation, Lung histopathology, Pulmonary
fibrosis.
