Male breast cancer
Male breast cancer-a 10-year review of 29 cases at Tanta University Hospital
Hanan Shawky(1), Samar Galal Younes(1) , Emad Sadaka(1), Salah El-Din Elgohary(2), Fersan A. Sallam(3)
Departments of 1Clinical Oncology, 2Surgery and 3Pathology, Faculty of Medicine, Tanta University
Abstract: Background /Aim: Male breast cancer (MBC) is a rare disease. To characterize male breast cancer in Tanta University Hospital, we systematically analyze available data on male breast cancer in our department.Methods: Twenty nine patients with non-metastatic MBC and a Karnofsky performance status (KPS) of ≥70,and adequate hematologic, renal and hepatic functions; were enrolled. All patients were symptomatic and diagnosed by preoperative fine needle aspiration cytology (FNAC) or biopsy. They were treated between January 2000 and January 2010 at Clinical Oncology Department, Faculty of Medicine, Tanta University Hospital, Egypt and Surgery Department, Faculty of Medicine, Tanta University Hospital, Egypt. No Prior therapy was permitted. Characteristics of the patients, and tumors were analyzed. Results: The study included 29 males non-metastatic invasive breast carcinomas with their age ranging from 28 to 80 years at the time of diagnosis (mean 52.8 years). Their tumors ranged in size from 1.5 cm to 8 cm. The majority of cases were T3, node positive and grade II or greater. They showed ER positivity in 19 cases (65.5%) and HER-2 positivity in 6 cases (20.7%). Median follow-up was 53 (6–120) months. The 5 and 10 year overall survival rates were 70.6%, and 57.0% respectively. Conclusion: The tumor biology of MBC is not significantly different from that of females, however, limited public awareness and absence of adequate screening for MBC result in delayed diagnosis and poor outcomes. Therefore, education, an appropriate system for early detection, and adequate treatment are prerequisite for improving outcomes, and men presenting any breast symptoms should be examined in the same manner and degree of urgency as in women to detect cancer at an early stage and better treatment outcomes.
[Hanan Shawky, Samar Galal Younes, Emad Sadaka, Salah El-Din Elgohary, Fersan A. Sallam. Male breast cancer-a 10-year review of 29 cases at Tanta University Hospital. Life Sci J 2013;10(1):1096-1102] (ISSN:1097-8135). http://www.lifesciencesite.com. 0
Keywords: male breast cancer, gynecomastia of male breast.
