Microwave-Assisted
Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine
and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety
Ahmed A. El-Kateb1,
Naglaa M. Abd El-Rahman1,2,*, Tamer S. Saleh1,3, Ibrahim
F. Zeid4, Mohamed F. Mady1
1Green Chemistry Department, National Research Centre,
Dokki, Cairo, 12622, Egypt
2Chemistry department, Faculty of Science, Jazan
University, Jazan, Saudi Arabia
3Chemistry Department, Faculty of Science, King
AbdulAziz University, Jeddah, Saudi Arabia
4Chemistry Department, Faculty of Science, El-Menoufia
University, Shebin El-Koam, El-Menoufia, Egypt
Abstract: A
facile, rapid and efficient microwave-assisted procedure for the synthesis of novel
pyrazole, pyrimidine, and pyrazolo[1,5-a]pyrimidines linked to sulfonyl
dibenzene moiety via the reaction of E-3-(N,N-dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one 3 with
the appropriate amines described here. In general, microwave procedure as an
eco-friendly energy source offers advantages such as a shorter reaction time,
simple workup, reaction selectivity and improves an overall yield compared with
conventional methods. The structures of all the compounds were confirmed by
analytical and spectral data.
[Ahmed A. El-Kateb, Naglaa M. Abd El-Rahman, Tamer S.
Saleh, Ibrahim F. Zeid, Mohamed F. Mady. Microwave-Assisted
Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines
Containing Aryl Sulfone Moiety.Life Sci J 2012;9(1):711-718]. (ISSN:
1097-8135). http://www.lifesciencesite.com.102
Keywords: Green chemistry; enaminone; pyrazolo[1,5-a]pyrimidine;
aryl Sulfone; microwave irradiation Full Text 102
