Misoprostol versus
Misoprostol versus
Surgical Intervention for Incomplete Abortion in Iran
Samie Karimi1, Minoo Rajaei2,
Mahboobeh Nasrollahi3 , Yaghoub Hamedi2, Kamelia
Madani3, Esmaeil Aliabadi4
1. Assistant professor, Gynecologic Oncology
Fellowship, Hormozgan University of Medical Sciences (HUMS), BandarAbbas,
Hormozgan, Iran
2. Associate professor, Fertility and Infertility
Research Center, Hormozgan University of Medical Sciences (HUMS), BandarAbbas,
Hormozgan, Iran
3. Resident of Obstetrics and Gynecology, Fertility
and Infertility Research Center, Hormozgan University of Medical Sciences
(HUMS), BandarAbbas, Hormozgan, Iran
4. Infectious and Tropical Disease Research Center,
Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran
Abstract: Introduction: Incomplete abortion is still one of the most important
causes of maternal mortality and morbidity in developing countries. Surgical
treatment is the standard treatment for incomplete abortion for years, but
Misoprostol usage is recently noted and is safe, effective, and low cost
treatment especially in areas with low resources. The aim of this study was to
compare the efficacy and safety of misoprostol and surgical treatment in
incomplete abortion. Methods: In this randomized clinical
trial study 150 women with incomplete abortion that referred to Shariati
hospital of Bandar-Abbas were evaluated. The patients were divided in 2 groups
randomly. Group A received 600 mg misoprostol and D&C was perform for Group
B. after 7 days, patients were reevaluated. Successful treatment approved by
ultrasonography. Data were analyzed by SPSS-16, descriptive study, Chi-square
and T-test. Significant level was set as P<0.05. Results: The
mean age of patients was 27.74 ± 5.84 years. Two groups were not different in
age, gestational age, and hemoglobin (P>0.05). The success rate after
treatment in surgery group (96%) significantly higher than the misoprostol
(10.66%) group (P=0.000). The patients who had failure of treatment with 2
course of misoprostol were underwent to D&C surgery and all of them were
successful. Conclusion: The results of this study and other study
indicate, although the success rate of misoprostol was lower than surgery, but
use of misoprostol for incomplete abortion in women is safe and could prevent
uterine rupture and unnecessary surgeries, particularly in women who anesthesia
or surgery is contraindicated. Large randomized trials focusing on patients
with incomplete abortion are needed to confirm these results.
[Karimi
S, Rajaei M, Nasrollahi M, Hamedi Y, Madani K, Aliabadi E. Misoprostol
versus Surgical Intervention for Incomplete Abortion in Iran. Life Sci J 2013;10(7s): 351-354]
(ISSN:1097-8135). http://www.lifesciencesite.com. 56
Keywords: Incomplete
abortion, Misoprostol, D&C surgery
