Prognostic Signifi
Prognostic Significance of Angiopoitein-2
in patients with Chronic Lymphocytic Leukemia
Zahra M.K(1).,
Eissa.S.A.(1) Tawfik. H.(2), Amira. Y. Abd-Elnaby.(1),
Tawfik.S. (3), Badr.E.A.,(1) and
Wageih. S. ELnaghy(4)
(1)Clinical Pathology Dept., Faculty of Medicine, Tanta
University,(2) Oncology Department, Faculty of
Medicine, Tanta University s(3)Internal medicine Dept., NRC, (4)
Microbiology department, Faculty of Medicine Tanta University.
[email protected]; [email protected]
Abstract: Introduction: Chronic
lymphocytic leukemia is a lymphoproliferative disorder characterized by
progressive lymphocytosis in the blood, bone marrow and lymphatic tissue. Angiopoietin-2
is a member of the angiopoietin family, which plays an important role in
angiogenesis, the formation of blood vessels from pre-existing blood vessels.
This study tried to throw light on the behavior of serum Ang-2 in newly
diagnosed B-CLL searching for possible value for its estimation. Patients
and method: The present study was conducted on 40 individuals. They
were subdivided into two groups: Control group: Included 10 healthy
individuals. Patient group: They were 30 newly diagnosed chronic lymphocytic
leukemia patients. Patients and controls were subjected to history taking
and clinical examination laying stress on splenomegaly, hepatomegaly and
lymphadenopathy. Laboratory investigations including; complete blood picture,
ESR, serum lactate dehydrogenase, kidney function tests, liver function tests,
estimation of serum angiopoitein-2 by ELISA technique. Absolute lymphocyte
count, bone marrow aspiration and Immunophenotypeing were performed in patients
only. Results: There was statistical significant decrease in
hemoglobin level and platelets counts in patients group as compared to control.
However, TLC and ESR were increased significantly in patients as compared to
control group. According to Rai classifications; ESR, Absolute
lymphocytic count, TLC, and absolute lymphocytic count, the percentage of
lymphocytes in BM, serum LDH, serum Ang-2 levels, and percentage of CD38
expression showed significantly progressive increase all through stages However
Platelet count and Hb level showed significantly progressive decrease with the
progress of the stages. There was a significant positive correlation between
the level of Ang-2 and the stage of CLL, CD38, total leucocytic count,percentage of lymphocytes in BM and LDH in CLL
patients. In conclusion, the present study shows that circulating
levels of Ang-2 were higher in CLL patients at diagnosis in comparison with
apparently healthy individuals
[Zahra M.K, Tawfik.H, Eissa.S.A , Amira.Y .Abd-Elnaby,
Tawfik.S, Badr.E and Wageih.S. ELnaghy. Prognostic Significance of
Angiopoitein-2 in patients with Chronic Lymphocytic Leukemia. Life
Sci J 2013;10(1):2726-2730] (ISSN:1097-8135). http://www.lifesciencesite.com.
Key words: Angiopoitein-2, Chronic lymphocytic leukemia (CLL).
