Protective Effect
Protective Effect of
Rosemary (Rosmarinus Officinalis) Leaves Extract on Carbon Tetrachloride
-Induced Nephrotoxicity in Albino Rats
Saber A. Sakr1 and
Hawazen A. Lamfon2
1. Zoology Department, Faculty of Science, Menoufia
University, Egypt
2. Department
of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi
Arabia
Abstract: Carbon
tetrachloride (CCl4) is an environmental pollutant that showed
toxicity in different organs. Exposure to CCl4 is known to
induce the formation of reactive oxygen species (ROS). Rosemary (Rosmarinus officinalis)
is a herb commonly used as spice and flavoring agents in food processing and is
useful in treatment of many diseases. The purpose of present study was to
investigate the protective role of rosemary on CCl4-induced renal
damage. Treating rats with 1.0ml /kg body weight of 10% CCl4 twice
a week for 6 weeks induced many histological changes in the kidney cortex .The
renal tubules lost their characteristic appearance and their lining epithelial
cells were degenerated. The glomeruli were atrophied and the renal blood
vessels were congested. The intertubular spaces were infiltrated by
inflammatory leucocytic cells. An increase in interstitial
expression of α-SMA was observed compared with control group. CCl4 also
caused marked elevation in serum creatinine and urea. Treating animals with CCl4 and
aqueous extract of rosemary led to an improvement, in both biochemical and
histopathological pictures. It is concluded that rosemary extract had a
protective effect against kidney injury induced by CCl4 and
this effect may be attributed to its antioxidant activity.
[Saber A. Sakr and Hawazen A. Lamfon. Protective
Effect of Rosemary (Rosmarinus Officinalis) Leaves Extract on Carbon
Tetrachloride -Induced Nephrotoxicity in Albino Rats. Life Sci J
2012; 9(3):779-785]. (ISSN: 1097-8135).http://www.lifesciencesite.com.112
Keywords: CCl4, Rosemary, Nephrotoxicity,
Creatinne, urea, α-SMA Full Text 112
