Protective effect
Protective effect of curcumin treatment on some organs in collagen-induced
arthritis in rats
Elshaimaa
M.Ibrahim1 , Abeer M. badr 1, Hiba Sibaii 2,
Amany S. E.El-Wakkad 2,Somaya El-Deeb.1
1 Zoology Department, Faculty of Science, Cairo
University, Egypt; 2 National Research Center, Dokki,
Cairo, Egypt. Corresponding author: [email protected]
Abstract: Objective: To evaluate the protective effect of curcumin
administration on various internal organs in collagen-induced arthritis
in rats. Material and methods: Animals were divided into
4 groups, 10 rats each. Group I: Normal control, Group
II was injected with DMSO, Group III arthritic rats, Group
IVarthritic rats received curcumin (100 mg/ Kg, i.p) thrice a week for 7
weeks prior to induction of arthritis. Rats were sacrificed and thymus,
spleen, liver, lung and kidney were collected for histopathological evaluation. Results: Mild
improvement in examined organs from rats injected with curcumin prior to
induction of arthritis as compared with arthritic group. Curcumin minimized the
complications caused by arthritis on the examined internal organs. Conclusion:The
study showed that the administration of curcumin prior to induction of
arthritis, to a certain extent minimized the complications caused by the
disease on the internal organs under study.
[Elshaimaa M.Ibrahim, Abeer M. badr, Hiba Sibaii,
Amany S. E.El-Wakkad ,Somaya El-Deeb. Protective effect of curcumin
treatment on some organs in collagen-induced arthritis in rats. J
Am Sci2012;8(10):413-419]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 60
Key
words: curcumin, arthritis, histopathological
evaluation. Full Text 60
