Serologic detectio
Serologic detection of anti Toxoplasma gondii infection in diabetic patients
Shahnaz Shirbazou (PhD) *1 , Ali Delpisheh (PhD, PostDoc) 2 ,Fatemeh Tabatabaie (PhD)3 ,Rahim Mokhetari (MSc) 4,Ghafor Tavakoli (MSc) 5 ,Sara Damghani 6 ,Yaser Tabaraei 7 , laila Aabasian8
1 Health Research center ,Baqiyatallah university of Medical Sciences, Department of Parasitology, Tehran,Iran
2 Department of Clinical Epidemiology and Prevention of Psychosocial Injuries, Research Centre, Ilam University of Medical Sciences, Ilam-Iran.
3 Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran,Iran.Email:[email protected]
4 Health Research center ,Baqiyatallah university of Medical Sciences, Department of Parasitology, Tehran,Iran
5Department of Medical Technology, Shahid Beheshti University, Tehran- Iran
6 Medical student, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7 MS in Biostatistics, Public health School-Health School-Sabzevar university of medical sciences (SUMS), Sabzevar, Iran.
8 Department of Parasitology, Ilam University of Medical Sciences, Ilam-Iran.
*Corresponding author: [email protected]
Abstract: Background: Toxoplasmosis is caused by the Toxoplasma gondii parasite. The parasite is intracellular and can result in severe complications leading to death in immuno-deficient patients in particular. Diabetes is an important factor that increases susceptibility and risk of various infections in the host. The present study focused on the serologic detection ofToxoplasma gondii infection in diabetic patients. Methodology: Through a case-control study, overall 184 serum samples including 91 from diabetic cases and 93 from healthy non-diabetic controls were investigated. Cases and controls were matched for age and gender. Serum samples were tested for sugar by an enzymatic method, and IgG antibodies were tested against Toxoplasma gondii by ELISA method. Results: The prevalence of IgG antibodies against Toxoplasma gondii in diabetic patients and healthy controls were 60.43% and 38% respectively. Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls (RR=2.21, 95%CI; 1.6-3.7, p=0.001). Conclusions: Diabetes may be caused byToxoplasma gondii. Presence of Toxoplasma gondii in the pancreas at the same time could directly undermines the pancreas cells. When β cells are destroyed, insulin secretion would then be affected. Probably the destruction of T. Gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes.
[Shahnaz Shirbazou, Ali Delpisheh, Fatemeh Tabatabaie, Rahim Mokhetari, Ghafor Tavakoli, Sara Damghani, Yaser Tabaraei, laila Aabasian, Serologic detection of anti Toxoplasma gondii infection in diabetic patients. Life Sci J 2013;10(7s): 313-315](ISSN:1097-8135). http://www.lifesciencesite.com. 47
Key words: Serologic, diabetic, Toxoplasma gondii , Infection
