Synthesis and Some
Synthesis
and Some Reactions of Some New Benzofuran Derivatives with Possible Biological
Activity
Nadia M. Saleh
Chemistry Department Faculty
of Science (Girls) Al-Azhar University, Nasr City, Cairo, Egypt
Abstract: 3-[4-Methoxy-6-hydroxy-5-benzofuranyl]
and 3-[4,6-dimethoxy-5-benzofuranyl] 1,3-diketo byrate (1a,b)(1) were
obtained from the reaction of [4-hydroxy (or methoxy) benzofuran-5-yl] methyl
ketone (Aa,b) with ethyl acetate in presence of
sodium metal. (1a,b) were reacted with α-cyanothioacetamide in the
presence of ammonium acetate(2) to give mercapto-3-carbonitrile-4-methyl-6-[4-methoxy-6-hydroxy-5-benzofuranyl]
pyridine (2a) and
2-mercapto-3-carbonitrile-4-methyl-6-[5,6-dimethoxy-5-benzofuranyl] pyridine (2b) (or
possible isomers (3a,b) respectively for the preparation of
some novel benzofuran derivatives (4a,b), (5a,b), (6a,b),
(7a,b), (8a-d), (9a,b) and (10a,b).
On the other hand sterylketone (11a-c) were
obtained by condensation of (Aa,b) with aromatic
aldehyde. Compounds(11b,c) gave new benzofuran
derivatives (12a,b), (13), (15), (16) and (17).
Selected members of the prepared compounds were screened for antimicrobial and
antifungal activities.
[Nadia M. Saleh. Synthesis and Some
Reactions of Some New Benzofuran Derivatives with Possible Biological Activity. J
Am Sci 2012;8(10):300-307]. (ISSN: 1545-1003). http://www.jofamericanscience.org.44
Keywords: New benzofuran derivatives are starting material
for the preparation of heterocyclic compounds containing benzofuran moieties Full Text 44
