The Effect of Time
The Effect of Time
Interval from Index Trauma on Results of Diagnostic Peritoneal Lavage in Animal
Samples
Mohammad Bassir Abolghassemi
Fakhree, Amrollah Bayat, Hamed Farhadi, Ramin Azhough
Department of General
Surgery, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical
Sciences, Tabriz, Iran
Abstract: Diagnostic
peritoneal lavage (DPL) is an invasive and highly sensitive diagnostic tool to
detect abdominal trauma. Despite recent trend to use non-invasive tools such as
FAST and CT scan to detect these injuries, DPL has its place in trauma
management particularly for hollow visceral injury. Using RBC count to detect
intestinal injuries has had low accuracy rate. WBC count, amylase, and alkaline
phophatase (ALP) levels have been useful in this regard but with some
controversies. The study was carried out on 90 rats, divided to 3 groups (30
rats each), and every group was subdivided randomly to 15 case and 15 control
rats. For case rats, perforations were done in the small intestine using a
needle. In all rats a catheter was placed in the peritoneum. Lavage of the
peritoneum was done through the catheter 1, 6, and 12 hours after the trauma
for first, second, and third group, respectively. WBC count was not different
between case and control rats 1 hour post-injury, but was increased 6 and 12
hours after perforation in case rats. Amylase and ALP levels were higher in
case rats in all of three groups compared to control rats. Further human
studies must be done to clarify the normal and abnormal values of WBC count,
amylase, and ALP levels of DPL analysis. Furthermore, the effect of time
interval on these parameters must be appreciated and taken into account in
interpreting the results of DPL to detect abdominal injuries as soon as
possible.
[Fakhree
MB, Bayat A, Farhadi H, Azhough R. The Effect of Time Interval from
Index Trauma on Results of Diagnostic Peritoneal Lavage in Animal Samples. Life Sci J 2013;10(7s):242-245]
(ISSN:1097-8135). http://www.lifesciencesite.com.
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Keywords: Diagnostic
peritoneal lavage; intestinal injuries; amylase; alkaline phosphatase
