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Prefixes can, for example, create a new word opposite in meaning to the word the prefix is attached to. They can also make a word negative or express relations of time, place or manner. Adding it to the beginning of one word changes it into another word. an affix placed before a word, base, or another prefix to modify a term's meaning, as by making the term negative, as un- in unkind, by signalling repetition, as re- in reinvent, or by indicating support, as pro- in proabolition.